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Filtered Search Results
=O | 5g | 537664091](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502148529.JPG-250.jpg)
eMolecules 953-26-4 | Ethyl 4-nitrocinnamate | Oakwood Chemical | MFCD00007380 | 221.212 | C11H11NO4 | 98.000 | CCOC(=O)\C=C\c1ccc(cc1)[N+]([O-])=O | 5g | 537664091
Ethyl 4-nitrocinnamate | Oakwood Chemical | 953-26-4 | MFCD00007380 | 221.212 | C11H11NO4 | 98.000 | CCOC(=O)\C=C\c1ccc(cc1)[N+]([O-])=O | 5g | 537664091
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Medchemexpress LLC Lisuride maleate | 19875-60-6 | 99.97% | 454.52 | 50 MG
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Lisuride (maleate) is a potent dopamine agonist that is believed to act directly on dopaminergic receptors. It is an ergot derivative. This compound has been shown to alleviate premenstrual mastalgia without significant side effects. Lisuride (maleate) has been studied in vivo, demonstrating 3-4 times higher potency when administered intraperitoneally (i.p.) compared to orally (p.o.). It effectively antagonizes motor depression and hypothermia induced by reserpine. At dosages as low as 0.10 mg/kg i.p., it is comparable in effectiveness to apomorphine and D-amphetamine in causing significant hypothermia. The product is for research use only and not sold to patients.
- Potent dopamine agonist
- Ergot derivative
- Therapeutic potential for premenstrual mastalgia
- Suitable for research applications
- High purity
- Versatile formulations
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Medchemexpress LLC Sumanirole (maleate) | 179386-44-8 | 99.8% | 319.31 | C15H17N3O5 | 10 MG
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Sumanirole maleate is the maleate salt of sumanirole, a selective dopamine D2 receptor full agonist used in neuroscience and pharmacology research to investigate dopaminergic signaling and disease models. It is supplied as a white to off-white solid with high purity and specified molecular formula C15H17N3O5 (MW 319.31).
- Selective D2 receptor full agonist for receptor pharmacology studies.
- High purity suitable for analytical and biological assays.
- White to off-white solid appearance for easy visual inspection.
- Available in small research quantities appropriate for in vitro studies.
- Stable when stored sealed at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
- CAS number 179386-44-8 for unambiguous chemical identification.
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Medchemexpress LLC Asenapine maleate | 85650-56-2 | 99.95% | 401.84 | 1 MG
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Asenapine maleate | 85650-56-2 | 99.95% | 401.84 | 1 MG
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Medchemexpress LLC AZD9496 maleate | 1639042-28-6 | 99.4% | 50 MG
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AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with an IC50 of 0.28 nM. It functions as an orally bioavailable selective estrogen receptor degrader (SERD), identified as a laboratory chemical.
- Potent and selective estrogen receptor (ERα) antagonist
- Orally bioavailable selective estrogen receptor degrader (SERD)
- Suitable for scientific research
- Used in signaling pathways
- For research use only
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Medchemexpress LLC Ro 25-6981 (Maleate) | 1312991-76-6 | 99.3% | 455.54 | 50 MG
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Ro 25-6981 Maleate is a potent, selective, and activity-dependent NR2B subunit-specific NMDA receptor antagonist. It demonstrates anticonvulsant and anti-parkinsonian activity and is considered to have potential for research into Parkinson's disease (PD).
- Potent, selective, and activity-dependent NR2B subunit-specific NMDA receptor antagonist
- Shows anticonvulsant activity
- Shows anti-parkinsonian activity
- Potential for Parkinson's disease (PD) research
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TARGETMOL CHEMICALS INC Monatepil maleate 1MG
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Also available in 5 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Monatepil maleate (AJ-2615 maleate) is an orally active Ca2+-channel and alpha1-adrenoceptor antagonist and non-competitive heparanoyl-coenzyme Acholesterol acyltransferase (ACAT) inhibitor with antihypertensive activity.Monatepil maleate is used in studies of hyperlipidemia and atherosclerosis. Monatepil maleate is used to study hyperlipidemia and atherosclerosis. Purity 96.28%
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Medchemexpress LLC PD-168077 maleate | 630117-19-0 | 99.6% | 450.49 | 100 MG
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PD-168077 maleate is a selective dopamine D4 receptor agonist with a Ki of 9 nM. It is for research use only. It shows high selectivity over other D2-like receptor family members and D1-like counterparts, as well as α1, α2, 5-HT1A, and 5-HT2A receptors. It evidences intrinsic activity at the D4 receptor and can induce locomotion in a dose-dependent manner. This product may be used in research related to neurological diseases, neurodegenerative diseases, depression, and Parkinson's disease.
- Selective dopamine D4 receptor agonist
- High selectivity over other receptor types
- Evidences intrinsic activity at the D4 receptor
- Induces locomotion in PD-168077-treated cells
- May be used in research for neurological diseases
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Medchemexpress LLC Avitinib maleate | 1557268-88-8 | 99.9% | 603.60 | 100 MG
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Avitinib (Abivertinib) maleate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M and wild-type EGFR. Avitinib maleate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate shows anticancer effects.
- Third-generation, irreversible and orally active selective EGFR inhibitor.
- Potent inhibition of EGFR L858R (IC50: 0.18 nM), EGFR T790M (IC50: 0.18 nM), and wild-type EGFR (IC50: 7.68 nM).
- BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma.
- Exhibits anticancer effects.
- Selectively inhibits mutant EGFR phosphorylation.
- Inhibits phosphorylation of downstream targets Akt and ERK1/2 in NCI-H1975 and HCC827 cells.
- Inhibits EGFR-mutant tumor growth in xenograft models over extended duration.
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Medchemexpress LLC 4-PPBP maleate | 201216-39-9 | MFCD00209909 | 99.6% | 409.52 g·mol-1 | C25H31NO4 | 25 MG
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4-PPBP maleate is a research-grade small-molecule sigma-1 receptor ligand and NMDA receptor modulator supplied as the maleate salt. It is intended for in vitro and preclinical studies and is not for human or clinical use. The compound is well characterized and provided with analytical purity suitable for laboratory research.
- Potent sigma-1 receptor ligand and agonist.
- Selective, non-competitive modulator of NR1a/2B NMDA receptors.
- Supplied as the maleate salt for stability and handling.
- High purity suitable for research applications (approximately 99.6%).
- Well-characterized molecular identity: C25H31NO4; MW 409.52 g·mol-1.
- Available in small laboratory pack sizes (25 mg).
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Medchemexpress LLC Dizocilpine maleate | 77086-22-7 | C20H19NO4 | 100 MG
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Dizocilpine maleate is a potent, selective, and non-competitive NMDA receptor antagonist. It effectively blocks currents induced by N-Me-D-Asp and can be utilized in various research applications, including inducing schizophrenia models.
- Potent, selective, and non-competitive NMDA receptor antagonist
- Causes progressive, long-lasting blockade of current induced by N-Me-D-Asp
- Used to induce schizophrenia models
- Kd of 37.2 nM in rat brain membranes
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Medchemexpress LLC NB-598 Maleate | 155294-62-5 | 99.4% | 565.74 | 2 MG
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NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE) that suppresses triglyceride biosynthesis through the farnesol pathway. It also functions as a click chemistry reagent, containing an Alkyne group.
- Potent and competitive inhibitor of squalene epoxidase (SE)
- Suppresses triglyceride biosynthesis through the farnesol pathway
- Click chemistry reagent containing an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
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Medchemexpress LLC Decursinol angelate | 130848-06-5 | 5 MG
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Decursinol angelate acts as a PKC activator and GDH inhibitor, with an IC50 of 1.432 μM against human GDH. It activates PKC, downregulates PKCα and PKCβII isoforms, and exhibits cytotoxic activity against cancer cells. Decursinol angelate also inhibits VEGF-induced autophosphorylation of VEGFR2, downstream p42/44 ERK and JNK-MAPK signaling pathways, and the angiogenesis process. It is applicable to research related to cancer and leukemia.
- Potent PKC activator
- Inhibits human glutamate dehydrogenase (IC50 1.432 μM)
- Exhibits cytotoxic activity against various human cancer cell lines
- Inhibits VEGF-induced angiogenesis
- Modulates macrophage polarization through NFκB and MAPK pathways
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Medchemexpress LLC Diethyl maleate | 141-05-9 | MFCD00009191 | 98.1% | 172.18 | C8H12O4 | 10g
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Diethyl maleate (DEM) is an orally available effective glutathione (GSH) depletor that crosses the blood-brain barrier Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0 1-0 5 mM Diethyl maleate selectively depletes GSH in liver lung and brain tissues exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO- Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3]
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Apexbio Technology LLC Mepyramine maleate 59-33-6 10mM (in 1mL DMSO)
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Mepyramine maleate (CAS 59-33-6) is a selective antagonist of the histamine H1 receptor exhibiting dissociation constants of 0 8 nM for H1 5200 nM for H2 and over 3000 nM for H3 receptors By blocking H1 receptor-mediated signaling it modulates pathways involved in allergic responses Mepyramine maleate is commonly utilized in experimental models of allergic diseases to investigate histamine-related mechanisms and to delineate the role of H1 receptor activity in immunological and inflammatory processes
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